National PhD in Precision Medicine (40th Cycle) A.Y. 2024-2025

ILARIA AMATO

Project: Digital image analysis of PD-L1 expression in different neoplastic settings


GABRIELE ANTONUCCIO

Project: Liver spheroids as model to investigate the pro-inflammatory and pro- fibrotic activity of Small-Extracellular Vesicles derived from Colorectal Cancer


GIORGIO ARCARESE

Project: Identificazione di receptor for advanced glycation end products (rage) in pazienti insulino resistenti e conclamata metainfiammazione affette da carcinoma vulvare: impatto sul microenviroment tumorale e strategie su lesioni drug-resistence.

Missions and other activities
  • Ricezione dati studio , 01/02/25 a 28/2/25, Catania Cannizzaro

SVEVA BAGNASCO

Project: Metabolomic question in schizophrenia


MARIA ELEONORA BIZZOCA

Project: Biomarker discovery in head and neck squamous cell carcinoma

Publications
  • Management of Vestibular Bone Fenestration with Periosteal Inhibition (PI) Technique During Alveolar Socket Preservation: A Case Report

ANTONELLA BORRELLI

Project: Enhancing the role of imaging in urothelial cancer diagnostic work up through novel pathways supported by AI algorithms and digital platforms with precision medicine approach


GIULIA BOZZARI

Project: Studio degli eventi molecolari che determinano la progressione del carcinoma tiroideo (TC)

Publications
  • Cancer stem cells and tumor-associated macrophages as mates in tumor progression: mechanisms of crosstalk and advanced bioinformatic tools to dissect their phenotypes and interaction

ELENA BUSCEMI

Project: Modellazione in vitro dell’influenza degli stimoli topologici sulla crescita di cellule cardiovascolari in scaffold porosi ingegnerizzati.


GIULIA BUSUITO

Project: Circulating yoT cells for monitoring clinical outcomes IN patients with advanced luNg cAncer undergoing first-line iMmune checkpOint iNhibitors: The CINNAMON prospective study

Publications
  • Chapter 8 – Molecular tumor board
  • Exploring the potential of multiomics liquid biopsy testing in the clinical setting of lung cancer
  • Recent advances in the use of liquid biopsy for the diagnosis and treatment of lung cancer
  • 49P Prognostic relevance of baseline exosome-delivered PD-1, PD-L1, pan-BTN3As and BTN3A1 in advanced cholangiocarcinoma patients: Can immune checkpoints act as a sentinel for predicting survival?
  • EP16.01-013 The Diagnostic Accuracy of Tumor Mutational Burden in Advanced NSCLC: An Individual Patient Data Meta-Analysis

DANIELE COLAZZO

Project: Identification of novel informative prognostic biomarker through transcriptional and mutational profiling of triple negative PMF and sAML patients


ALESSIA COSENTINO

Project: La piattaforma ARIANNA nella ricerca clinica, biomedica e bioinformatica su malattie rare


SARA CRUPI

Project: Riduzione dell’apoptosi dei cardiomiociti indotta da Doxorubicina, sviluppando un miRNA mimic che svolga l’azione di sponge sul lncRNA LINC00339.


COSTANZA DIELI

Project: Studio del ruolo dei linfociti t yo e della loro modulazione indotta dal microambiente tumorale nella progressione del glioblastoma


GIACOMO FERRANTELLI

Project: The role of circulating tumor cells (CTCs), extracted by liquid biopsy, as a potential indicator of response to integrated chemo-radiotherapy treatments in patients with “limited-stage” small cell lung cancer (SCLC) potentially suitable for consolidation immunotherapy.

Publications
  • Concomitant chemoradiation therapy in the Radiation Oncology Unit: can it make a difference?
  • “Radiotherapy directed to inferior vena cava tumor thrombus among patients with renal cell carcinoma: an illustrative case and review of the literature”
  • Radioterapia a intensità modulata con boost simultaneo più cetuximab in pazienti con carcinoma a cellule squamose in stadio localmente avanzato del distretto testa collo: è fattibile nella pratica clinica quotidiana? [Concurrent simultaneous integrated boost radiotherapy and cetuximab in head and neck squamous cell cancer patients: is it feasible in daily clinical practice?]
  • Lattice radiotherapy in inflammatory breast cancer: report of a first case treated with curative aim
  • Locally advanced squamous cervical carcinoma (M0): management and emerging therapeutic options in the precision radiotherapy era
  • Modulation of Radiation Doses and Chimeric Antigen Receptor T Cells: A Promising New Weapon in Solid Tumors—A Narrative Review
  • Recurrent Gynecological Tumors in Previously Irradiated Patients. Does Re-Irradiation with Stereotactic Body Radiotherapy Have a Role? A Systematic Review
  • Stereotactic boost on residual disease after external-beam irradiation in clinical stage III non-small cell lung cancer: mature results of stereotactic body radiation therapy post radiation therapy (SBRTpostRT) study
  • A non-surgical COMBO-therapy approach for locally advanced unresectable pancreatic adenocarcinoma: preliminary results of a prospective study
  • Gastroparesis, Thymoma, and Asymptomatic Myasthenia: A Rare Clinical Scenario
  • Impressive Results after “Metabolism-Guided” Lattice Irradiation in Patients Submitted to Palliative Radiation Therapy: Preliminary Results of LATTICE_01 Multicenter Study
  • La Glomerulonefrite membranosa con sovrapposizione crescentica [Membranous glomerulonephritis with crescent overlapping]
  • Comment to case report encapsulating peritoneal sclerosis (EPS): Presentation without preceding symptoms
  • A case of acute EPS with local cocoon formation in a patient on peritoneal dialysis
  • Comment on New therapeutics for ANCA-associated vasculitis: 10 years devoted to lessen toxicity
  • Acute kidney injury in a patient with metabolic syndrome

MANFREDI GIAMMANCO

Project: Effetti della bromelina e della iontoforesi sclerale con luteina sulla degenerazione maculare senile valutati tramite oct, angio-oct ed intelligenza artificiale


MARTINA GRECO

Project: Il ruolo del cfDNA come potenziale biomarcatore predittivo e prognostico nel setting precoce del tumore della mammella

Publications
  • Non-Small Cell Lung Cancer Harboring Concurrent EGFR Genomic Alterations: A Systematic Review and Critical Appraisal of the Double Dilemma
  • Chapter 7 – Early detection screening: myth or reality?
  • Correlation between sentinel lymph node biopsy and non-sentinel lymph node metastasis in patients with cN0 breast carcinoma: comparison of invasive ductal carcinoma and invasive lobular carcinoma
  • Comprehensive Axillary Management of Clinically Node-Positive (cN+) Breast Cancer Patients: A Narrative Review on Neoadjuvant Chemotherapy
  • unusual presentation of luminal breast carcinoma metastatic to the brain and coma: a case report of dramatic response to abemaciclib and literature review

JULIETTE AIMEE GUERRY

Project: Integrating Deep Learning-based radiomics and circulating tumor DNA for the evaluation and prediction of response in patients with advanced Non-Small Cell Lung Cancer.


FABIO LEPORE

Project: Studio dell’impatto biologico svolto dai fibroblasti associati al tumore nell’adenocarcinoma duttale pancreatico e sviluppo di nuovi approcci terapeutici


TANCREDI LO PRESTI

Project: Create a prototypal function to interoperate health, environment, and climate data, to support primary prevention interventions


GIOVANNA ERIKA LOMEO

Project: Creazione di un sistema di Intelligenza Artificiale (IA) per la diagnosi precoce dell’iperplasia endometriale atipica e il carcinoma endometriale dallo stadio 𝑰𝒂 allo stadio 𝑰𝑰𝒃 (FIGO) attraverso l’integrazione di metodiche di imaging con la profilazione molecolare.


LUDOVICA LUCCHESI PALLI

Project: Sviluppo di nanosistemi teranostici multifunzionali a base di carbon nanodots (cds)

Missions and other activities
  • Corso di formazione FISV online in Advanced Technologies in Single Cell Omics

SIMONE MAS

Project: Analisi meccano-biologica dell’adenocarcinoma pancreatico duttale (PDAC): sviluppo di nuove terapie anti-fibrotiche


ANNA MASUCCI

Project: Definizione di un sistema di classificazione biochimico-clinico per il Morbo di Parkinson: un approccio integrato e personalizzato basato sui biomarcatori molecolari e genetici

Publications
  • Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice
  • Sex and Gender in Ageing and Longevity: Highlights From an International Course
  • The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)
  • PIWI-RNAs Small Noncoding RNAs with Smart Functions: Potential Theranostic Applications in Cancer
Missions and other activities
  • 3thCourse Clinical Laboratory Medicine in the Third Millennium ERICE 2024

AURORA MAZZOLA

Project: The role of gene expression levels of mismatch repair (MMR) genes in the homologous recombination (HR)-associated tumors


LOKMAN RACHID MELHANI

Project: Development of an algorithm based on Deep Learning and AI for the prediction, monitoring, and control of the pandemic events


MICHELE MENDITTO

Project: Identificazione e analisi di molecole ad attività readthrough per il recupero della funzione genica in malattie genetiche rare e su base genetica causate dalla presenza di mutazioni di stop


FRANCESCO ORILIO

Project: Analisi Bioinformatica dei ncRNA in modelli cellulari 3D: Implicazioni per il Cancro al Seno e l’Obesita


LAURA PELLERITO

Project: A biomechanical approach to aortic dissection


BARBARA PERUGINI

Project: La valorizzazione e offerta di competenze e tecnologie come leva per il raggiungimento della sostenibilità in una Biobanca per Malattie Rare: la collaborazione tra Università e Impresa può essere un valore aggiunto e accelerare questo processo?


ANTONIO PRINZI

Project: Metastasi Cerebrali da Carcinoma Differenziato Tiroideo: Diagnosi Precoce e Strategie di Trattamento

Publications
  • Impact of dyslipidemia and lipid-lowering therapy with statins in patients with neuroendocrine tumors
  • Clinical management of indeterminate thyroid nodules needs to be revisited. New evidence for a personalized approach to the problem
Missions and other activities
  • Congresso di endocrinologia oncologica e malattie ipotalamo-ipofisarie, 20-22 febbraio 2025, Milano
  • Ricerca presso Università di Zurigo, 5 aprile-8 maggio 2025

MATTIA PUGLISI

Project: Study of genetic interaction between BRCA1/2 genes and thetamediated end-joining (TMEJ) pathway components in prostate cancer patients

Publications
  • Association of location of BRCA1/2 pathogenic variants with benefit from PARP-inhibitors in metastatic castration-resistant prostate cancers: Results from the PROGRESS study
  • Pregnancy and miscarriage before epithelial ovarian cancer (EOC) diagnosis in patients carrying germline BRCA1/BRCA2 pathogenic variants

MUHAMMAD REHAN

Project: Enhancing Infection Control in High-Risk Hospital Environments Using Computer Vision and Blockchain Technology to trace hygenization process

Publications
  • Supply Chain Management Using an Industrial Internet of Things Hyperledger Fabric Network

ENRICO SANGIORGIO

Project: Personalized transarterial embolization planning simulator

Publications
  • Investigating the relationship between geometry and hemodynamics in an experimentally derived murine coronary computational model

FEDERICA SAPUTO

Project: Applicazione dell’intelligenza artificiale alla risonanza magnetica preoperatoria per la previsione della risposta patologica completa in pazienti con carcinoma della mammella triplo negativo e HER2 positivo trattate con chemioterapia neoadiuvante.


ANTONIO SEGRETO

Project: Valutazione dello strain aortico mediante ecocardiografia 3D Speckle Tracking: creazione di un modello predittivo che integri dati clinici, anatomo-patologici e di strain longitudinale per prevedere il rischio di progressione delle patologie aortiche

Publications
  • Extensive versus conventional treatment for type a aortic dissection: preliminary results of ascyrus medical dissection stent

SERENA SERRATORE

Project: Sviluppo di una terapia cellulare basata sull’utilizzo di cellule staminali e della loro progenie cellulare per la rigenerazione cardiaca


SARA SGURO

Project: Variations in Galectin-1 levels in cancer-associated fibroblasts (CAF) and their influence on the immunotherapy response in melanoma patients

Publications
  • Can different selection strategies increase diagnostic power for the identification of lynch syndrome- associated colorectal cancer patients?

MARIA SPECIALE

Project: Precision Strategies for Oxidative Stress-Targeted Therapy and Immune Modulation in Multiple Myeloma Progression


VALERIA SPINNATO

Project: Tailoring Monoclonal Antibody Therapy: the role of Therapeutic Drug Monitoring and Dosage Adaptation

Publications
  • BRCA-associated hereditary male cancers: can gender affect the prevalence and spectrum of germline pathogenic variants?
  • Understanding the treatment algorithm of patients with advanced G2 gastroenteropancreatic neuroendocrine neoplasms: A single-institution retrospective analysis
  • The Diagnostic Accuracy of Tumor Mutational Burden in Advanced NSCLC: An Individual Patient
  • New Challenges in the era of Immunotherapy and Precision

CRISTINA TOMARCHIO

Project: Il ruolo dei geni KIR e dell’inflammasoma nella Sclerosi Multipla.

Publications
  • An Optimized NGS Workflow Defines Genetically Based Prognostic Categories for Patients with Uveal Melanoma

MARIKA TRISCARI BARBERI

Project: Utilizzo della radiomica per la valutazione prognostica e terapeutica dei pazienti affetti da tumori gastrointestinali stromali

Publications
  • Investigating changes in mediastinal anatomy on severe trauma using post-mortem CT scans and multiparametric 3-D reconstructions: a case series of major trauma

ALESSIA VARVARÁ

Project: Utilizzo della radiomica per la valutazione prognostica e terapeutica dei pazienti affetti da tumori gastrointestinali stromali


ROBERTA VASSALLO

Project: Utilizzo della radiomica per la valutazione prognostica e terapeutica dei pazienti affetti da tumori gastrointestinali stromali

Publications
  • Molecular Biomarkers of Neurodegenerative Disorders: A Practical Guide to Their Appropriate Use and Interpretation in Clinical Practice
  • Sex and Gender in AgeiCaruAgeing (2024). Sex and Gender in Ageingational Course
  • The role of Killer immunoglobulin-like receptors (KIRs) in the genetic susceptibility to non-celiac wheat sensitivity (NCWS)
Missions and other activities
  • 3thCourse Clinical Laboratory Medicine in the Third Millennium ERICE 2024

ROBERTA VELLA

Project: /

Publications
  • Personalized nutrition after discharge for pancreatic surgery: A study protocol